Kesejahteraan Psikologis dan Kualitas Hidup Pasien Kanker Serviks dengan Kemoterapi
Abstract
Cervical cancer is a life-threatening gynecological problem in women worldwide. Chemotherapy is one of the treatment options for cervical cancer patients. The side effects of chemotherapy can cause psychological discomfort which has an impact on quality of life. The purpose of the study was to analyze the relationship between psychological well-being and quality of life of cervical cancer patients with chemotherapy. The cross-sectional study approach method was conducted on 89 cervical cancer patients with chemotherapy. Univariate analysis was used to describe the research variables presented in frequency and percentage tables. The chi square test was used to correlate the variables of psychological well-being and quality of life. Psychological well-being was assessed with Ryff's Psychological Well-Being Scale (RPWB) questionnaire with 28 questions. The quality of life of research respondents was assessed with The EORTC Core Quality of Life Questionnaire (QLQ-C30) questionnaire with 30 questions. The results showed that 41 respondents (75.55%) had good psychological well-being and good quality of life while 16 respondents (47.06%) had poor psychological well-being and poor quality of life. The results of the chi square test obtained a p-value of 0.036 which means p < α (α = 0.05). These results indicate that psychological well-being has a significant relationship with quality of life in cervical cancer patients with chemotherapy. The conclusion shows that cancer has a negative impact on the psychological well-being and quality of life of cancer patients. The psychological well-being status and quality of life of cervical cancer patients need to be assessed to reduce side effects during chemotherapy.
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Gaffney DK, Hashibe M, Kepka D, Maurer KA, Werner TL. Too many women are dying from cervix cancer: Problems and solutions. Gynecol Oncol. 2018;151(3):1–21.
Olusola P, Banerjee HN, Philley J V., Dasgupta S. Human Papilloma Virus-Associated Cervical Cancer and Health Disparities. Cell. 2019;622(8):1–12.
WHO. Global Cancer Observatory: Indonesia. Int Agency Res Cancer. 2022;1–2.
Feng R, Su Q, Huang X, Basnet T, Xu X, Ye W. Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration? Cancer Commun. 2023;43(1):75–86.
Ngoma M, Autier P. Cervical cancer prevention. Cancer Med Sci. 2019;952(13):1–6.
Cibula D, Pötter R, Planchamp F, Avall-Lundqvist E, Fischerova D, Haie Meder C, et al. The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology guidelines for the management of patients with cervical cancer. Radiother Oncol [Internet]. 2018;127(3):1–13. Available from: https://doi.org/10.1016/j.radonc.2018.03.003
Ramirez PT, Frumovitz M, Pareja R, Lopez A, Vieira M, Ribeiro R, et al. Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer. N Engl J Med. 2018;379(20):1895–904.
Gallotta V, Conte C, Federico A, Vizzielli G, Gueli Alletti S, Tortorella L, et al. Robotic versus laparoscopic radical hysterectomy in early cervical cancer: A case matched control study. Eur J Surg Oncol [Internet]. 2018;44(6):754–9. Available from: https://doi.org/10.1016/j.ejso.2018.01.092
Ryu SY, Kim MH, Nam BH, Lee TS, Song ES, Park CY, et al. Intermediate-risk grouping of cervical cancer patients treated with radical hysterectomy: A Korean Gynecologic Oncology Group study. Br J Cancer [Internet]. 2014;110(2):278–85. Available from: http://dx.doi.org/10.1038/bjc.2013.716
Noh JM, Park W, Kim YS, Kim JY, Kim HJ, Kim J, et al. Comparison of clinical outcomes of adenocarcinoma and adenosquamous carcinoma in uterine cervical cancer patients receiving surgical resection followed by radiotherapy: A multicenter retrospective study (KROG 13-10). Gynecol Oncol [Internet]. 2014;132(3):618–23. Available from: http://dx.doi.org/10.1016/j.ygyno.2014.01.043
Zhang YF, Fan Y, Zhang P, Ruan JY, Mu Y, Li JK. Cervical Cancer Recurrence and Patient Survival After Radical Hysterectomy Followed by Either Adjuvant Chemotherapy or Adjuvant Radiotherapy With Optional Concurrent Chemotherapy: A Systematic Review and Meta-Analysis. Front Oncol. 2022;12(3):1–9.
ALCI A, Aytekin O, Ersak B, Kilic F, Oktar O, Caner C, et al. The role of neoadjuvant chemotherapy before radical surgery in stage IB2/IIA2 squamous cell cervical cancers. BMC Womens Health. 2024;24(1):1–9.
Ikeda M, Shida M, Shigeta S, Nagase S, Takahashi F, Yamagami W, et al. The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: A report from the Japan society of gynecologic oncology (JSGO) guidelines evaluation committee. J Gynecol Oncol. 2021;32(3):1–13.
Ramanathan K, Antognini D, Combes A, Paden M, Zakhary B, Ogino M, et al. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- research that is available on the COVID-19 resource centre - including this for unrestricted research re-use a. Lancet. 2020;395:591–603.
Wang YH, Li JQ, Shi JF, Que JY, Liu JJ, Lappin JM, et al. Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies. Mol Psychiatry [Internet]. 2020;25(7):1–13. Available from: http://dx.doi.org/10.1038/s41380-019-0595-x
Maree JE, Jansen Van Rensburg JJM. Suitability of quality-of-life outcome measures in palliative care in the South African setting. Palliat Support Care. 2016;14(2):118–28.
Tax C, Steenbergen ME, Zusterzeel PLM, Bekkers RLM, Rovers MM. Measuring health-related quality of life in cervical cancer patients: A systematic review of the most used questionnaires and their validity. BMC Med Res Methodol [Internet]. 2017;17(1):1–9. Available from: http://dx.doi.org/10.1186/s12874-016-0289-x
Khalil J, Bellefqih S, Sahli N, Afif M, Elkacemi H, Elmajjaoui S, et al. Impact of cervical cancer on quality of life: beyond the short term (Results from a single institution). Gynecol Oncol Res Pract [Internet]. 2015;2(1):2–7. Available from: http://dx.doi.org/10.1186/s40661-015-0011-4
de Rooij BH, Ezendam NPM, Nicolaije KAH, Lodder P, Vos MC, Pijnenborg JMA, et al. Survivorship care plans have a negative impact on long-term quality of life and anxiety through more threatening illness perceptions in gynecological cancer patients: the ROGY care trial. Qual Life Res. 2018;27(6):1533–44.
Xiong NN, Wei J, Ke MY, Hong X, Li T, Zhu LM, et al. Illness perception of patients with functional gastrointestinal disorders. Front Psychiatry. 2018;9(4):1–10.
Badr H. Psychosocial Interventions for Patients With Advanced Cancer and Their Families. Am J Lifestyle Med. 2016;10(1):53–63.
Fadhil A. Evaluasi Properti Psikometris Skala Psychological Well-Being (PWB) Versi Indonesia. J Pendidik Tambusai [Internet]. 2021;5(2):46666–4674. Available from: file:///C:/Users/Asus/Downloads/1622-Article Text-3160-1-10-20210824.pdf
Perwitasari DA, Atthobari J, Dwiprahasto I, Hakimi M, Gelderblom H, Putter H, et al. Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia. Jpn J Clin Oncol. 2011;41(4):519–29.
Song B, Ding C, Chen W, Sun H, Zhang M, Chen W. Incidence and mortality of cervical cancer in China, 2013. Chinese J Cancer Res. 2017;29(6):471–6.
Ghebre RG, Grover S, Xu MJ, Chuang LT, Simonds H. Cervical cancer control in HIV-infected women: Past, present and future. Gynecol Oncol Reports [Internet]. 2017;21(June):101–8. Available from: http://dx.doi.org/10.1016/j.gore.2017.07.009
Mvunta DH, August F, Dharsee N, Mvunta MH, Wangwe P, Ngarina M, et al. Quality of life among cervical cancer patients following completion of chemoradiotherapy at Ocean Road Cancer Institute (ORCI) in Tanzania. BMC Womens Health [Internet]. 2022;22(1):426. Available from: https://doi.org/10.1186/s12905-022-02003-6
Hanprasertpong J, Geater A, Jiamset I, Padungkul L, Hirunkajonpan P, Songhong N. Fear of cancer recurrence and its predictors among cervical cancer survivors. J Gynecol Oncol. 2017;28(6):1–11.
Huang W, Liu J, Xu K, Chen H, Bian C. PD-1/PD-L1 inhibitors for advanced or metastatic cervical cancer: From bench to bed. Front Oncol. 2022;12(10):1–13.
Han HR, Song Y, Kim M, Hedlin HK, Kim K, Lee H Ben, et al. Breast and cervical cancer screening literacy among Korean American women: A community health worker-led intervention. Am J Public Health. 2017;107(1):159–65.
Tian X, Yang F, Li F, Ran L, Chang J, Li J, et al. A comparison of different schemes of neoadjuvant chemotherapy followed by concurrent chemotherapy and radiotherapy for locally advanced cervical cancer: A retrospective study. Cancer Manag Res. 2021;13:8307–16.
Tilsed CM, Fisher SA, Nowak AK, Lake RA, Lesterhuis WJ. Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action. Front Oncol. 2022;12(7):1–18.
Karadag Arli S, Bakan AB, Aslan G. Distribution of cervical and breast cancer risk factors in women and their screening behaviours. Eur J Cancer Care (Engl). 2019;28(2):1–8.
Darj E, Chalise P, Shakya S. Barriers and facilitators to cervical cancer screening in Nepal: A qualitative study. Sex Reprod Healthc [Internet]. 2019;20(7491):20–6. Available from: https://doi.org/10.1016/j.srhc.2019.02.001
Lewandowska A, Rudzki G, Lewandowski T, Próchnicki M, Rudzki S, Laskowska B, et al. Quality of life of cancer patients treated with chemotherapy. Int J Environ Res Public Health. 2020;17(19):1–16.
Tremolada M, Taverna L, Bonichini S, Basso G, Pillon M. Self‐esteem and academic difficulties in preadolescents and adolescents healed from paediatric leukaemia. Cancers (Basel). 2017;9(6).
Mitchell UA, Ailshire JA, Brown LL, Levine ME, Crimmins EM. Education and Psychosocial Functioning among Older Adults: 4-Year Change in Sense of Control and Hopelessness. Journals Gerontol - Ser B Psychol Sci Soc Sci. 2018;73(5):849–59.
Isfahani P, Corani Bahador R, Peirovy S, Afshari M. Quality of Life among Cancer Patients in Iran. Heal Educ Heal Promot. 2022;10(1):23–31.
Lacomba-Trejo L, Mateu-Mollá J, Bellegarde-Nunes MD, Delhom I. Are Coping Strategies, Emotional Abilities, and Resilience Predictors of Well-Being? Comparison of Linear and Non-Linear Methodologies. Int J Environ Res Public Health. 2022;19(12):1–13.
Annunziata MA, Muzzatti B, Flaiban C, Gipponi K, Carnaghi C, Tralongo P, et al. Long-term quality of life profile in oncology: a comparison between cancer survivors and the general population. Support Care Cancer. 2018;26(2):651–6.
Bager L, Elsbernd A, Nissen A, Daugaard G, Pappot H. Danish translation and pilot testing of the European Organization for Research and Treatment of Cancer QLQ-TC 26 (EORTC QLQ-TC26) questionnaire to assess health-related quality of life in patients with testicular cancer. Health Qual Life Outcomes. 2018;16(1):1–6.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer. 2018;68(1):7–30.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
Jacob J, Palat G, Verghese N, Chandran P, Rapelli V, Kumari S, et al. Health-related quality of life and its socio-economic and cultural predictors among advanced cancer patients: Evidence from the APPROACH cross-sectional survey in Hyderabad-India. BMC Palliat Care. 2019;18(1):1–12.
Mentella MC, Scaldaferri F, Ricci C, Gasbarrini A, Miggiano GAD. Cancer and mediterranean diet: A review. Nutrients. 2019;11(9):1–25.
Licu M, Ionescu CG, Paun S. Quality of Life in Cancer Patients: The Modern Psycho-Oncologic Approach for Romania—A Review. Curr Oncol. 2023;30(7):6964–75.
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